報 告 人：K. Jimmy Hsia教授（UIUC）
報告題目：Micro-Nanotechnologies to Study Mechanobiology & Janus Particles
報告時間：2013年11月11日10:00-11:00am
報告地點：浙江大學玉泉校區教五-333
Abstract
Nanotechnologies have been widely used in studies of physical sciences and engineering for several decades. Recently they have found applications in biology and medicine. These technologies can have profound impact on cell biology, tissue engineering, cancer, and disease research. In this presentation, I will first present a case where micro- and nanotechnologies play an important role in studying the mechanisms of mechanobiology, e.g., cell responses to different mechanical environment with nanoscale patterns. In particular, I will highlight an experimental study to identify the roles of cell-matrix interaction and cell-cell interaction. These micro and nanoscale patterns may also be used to control cell cluster formation and cell movement for potential medical applications. The second part of my presentation is an attempt to understand the mechanisms controlling the formation of nanoscale Janus particles fabricated by colleagues in chemistry department who are experts in DNA-based Janus particle manufacturing. Janus particles are particles with two distinct properties on the two halves of the particle surface. Because of the property, they can often self-assemble into different shapes and can be used for unique applications such as drug delivery. Molecular dynamics simulations are performed to study how two different types of molecules segregate on the surface of gold nano-particles. The simulation results lead to a couple of surprise finding.
Biography:
K. Jimmy Hsia is Professor of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign (UIUC). He received his B.S. in Engineering Mechanics from Tsinghua University, Beijing, China, and his Ph.D. in Mechanical Engineering from MIT. His research interests include deformation and failure mechanisms of materials at ambient and elevated temperatures, mciro/nanomechanics of materials, nanoscale phenomena in biomaterials, and applications of micro-/nanotechnologies in materials, device fabrication, and biological research. He has served on the Editorial Advisory Board, Acta Mechanica Solida Sinica, and as Guest Editor/Co-Editor for several special issues of Materials Science and Engineering. He is a Fellow of American Association for the Advancement of Science (AAAS), a Fellow of American Society of Mechanical Engineers (ASME), and recipient of an NSF Research Initiation Award, a Max-Planck Society Scholarship, a Japan Society for Promotion of Science Fellowship, and an Associate of Center for Advanced Study at UIUC. From 2005-2007, Jimmy Hsia served as Founding Director of Nano and Bio Mechanics Program in the Directorate for Engineering at NSF. He served as Associate Dean of Graduate College at UIUC, and Associate Vice Chancellor for Research for New Initiatives at UIUC. He is the current Director of Global Enterprise of MicroMechanics and Molecular Medicine (GEM4), an organization founded by Prof. Subra Suresh, former Director of NSF and the new President of Carnegie Mellon University.
