報(bào)告題目：The role of thermal undulations in cell-biological systems
報(bào)告人：香港大學(xué)機(jī)械工程系 Yuan Lin 教授
報(bào)告時(shí)間：12月25日(周五) 下午15:00-16:00
報(bào)告地點(diǎn)：浙江大學(xué)玉泉校區(qū)教12-118
報(bào)告摘要：When immersed in a thermal reservoir, objects like cell membrane and actin filament are susceptible to bending deformations due to thermal excitations. These types of thermal undulations can be both disruptive and useful which will be demonstrated through two examples in this talk. First, we will show that the density of molecular bonds, connecting the cytoskeleton of a cell to the extracellular matrix, must be larger than a certain value in order to “suppress” the fluctuations of the membrane and hence enforce stable adhesion. This finding explains recent experiment observations that tight cell adhesion patches can only be formed when bonds were spaced more closely together than a critical spacing, whereas almost no adhesions between the cell and the substrate were formed for spacing larger than this critical value.
The second example concerns with the actin-based motility of cell and Listeria. We will demonstrate the essential role of thermal undulations in the generation of propelling forces, large enough for the continuous movements of cell and Listeria, by unidirectional actin polymerizations. A mechanics model is proposed to describe the force generation capability of actin filaments and the comparisons between model predictions and various experiment data will also be presented.
報(bào)告人簡(jiǎn)介：
Yuan Lin，香港大學(xué)機(jī)械工程系助理教授。1999、2001年分別從清華大學(xué)獲得本科、碩士學(xué)位，2006年獲美國(guó)布朗大學(xué)應(yīng)用數(shù)學(xué)碩士學(xué)位，2007年底從美國(guó)布朗大學(xué)獲得固體力學(xué)博士學(xué)位，導(dǎo)師為國(guó)際固體力學(xué)大師L. Ben Freund教授，2008年開(kāi)始任教于香港大學(xué)。他的主要研究領(lǐng)域包括固體力學(xué)，分子和細(xì)胞生物力學(xué)等。在JMPS，IJSS，PRE，Acta Materialia等國(guó)際知名期刊上發(fā)表多篇學(xué)術(shù)論文。
歡迎大家光臨！
