報告題目：The role of thermal undulations in cell-biological systems
報告人：香港大學機械工程系 Yuan Lin 教授
報告時間：12月25日(周五) 下午15:00-16:00
報告地點：浙江大學玉泉校區教12-118
報告摘要：When immersed in a thermal reservoir, objects like cell membrane and actin filament are susceptible to bending deformations due to thermal excitations. These types of thermal undulations can be both disruptive and useful which will be demonstrated through two examples in this talk. First, we will show that the density of molecular bonds, connecting the cytoskeleton of a cell to the extracellular matrix, must be larger than a certain value in order to “suppress” the fluctuations of the membrane and hence enforce stable adhesion. This finding explains recent experiment observations that tight cell adhesion patches can only be formed when bonds were spaced more closely together than a critical spacing, whereas almost no adhesions between the cell and the substrate were formed for spacing larger than this critical value.
The second example concerns with the actin-based motility of cell and Listeria. We will demonstrate the essential role of thermal undulations in the generation of propelling forces, large enough for the continuous movements of cell and Listeria, by unidirectional actin polymerizations. A mechanics model is proposed to describe the force generation capability of actin filaments and the comparisons between model predictions and various experiment data will also be presented.
報告人簡介：
Yuan Lin，香港大學機械工程系助理教授。1999、2001年分別從清華大學獲得本科、碩士學位，2006年獲美國布朗大學應用數學碩士學位，2007年底從美國布朗大學獲得固體力學博士學位，導師為國際固體力學大師L. Ben Freund教授，2008年開始任教于香港大學。他的主要研究領域包括固體力學，分子和細胞生物力學等。在JMPS，IJSS，PRE，Acta Materialia等國際知名期刊上發表多篇學術論文。
歡迎大家光臨！
